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Background: Although remote ischaemic preconditioning (RIP) provides protection against myocardial ischaemia and reperfusion injury during cardiac surgery, it is not widely used. Systemic intermittent hypoxic-hyperoxic training (IHHT) may be a suitable alternative. Methods: This is a prospective, single-centre, randomised controlled trial. 127 patients with ischaemic heart disease and indication for coronary artery bypass graft (CABG) surgery from the Cardiology Clinic IM Sechenov First Moscow State…

Aim: To compare a program based on intermittent hypoxia-hyperoxia training (IHHT) consisting of breathing hypoxic-hyperoxic gas mixtures while resting to a standard exercise-based rehabilitation program with respect to cardiorespiratory fitness (CRF) in older, comorbid cardiac outpatients. Materials and methods: Thirty-two cardiac patients with comorbidities were randomly allocated to IHHT and control (CTRL) groups. IHHT completed a 5-week program of exposure to hypoxia-hyperoxia while resting, CTRL…

Background: Repeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia-hyperoxia exposure in coronary artery disease (CAD) patients (New York Heart Association II-III). Hypothesis: IHHT improves exercise tolerance, cardiometabolic profile, and quality of life in CAD patients. Methods: The study design was a nonrandomized, controlled, before-and-after trial. Forty-six CAD patients volunteered to take…

SummaryOvertraining syndrome (OTS) is a major concern among endurance athletes and is a leading cause in preventing them to perform for long periods. Intermittent exposure to hypoxia has been shown to be an effective way of improving perfor- mance without exercising. Aim of this pilot study was to evaluate intermittent hypoxia–hyperoxia training combined with light exercise as an intervention to facilitate athletes with OTS to…

IntroductionIntermittent hypoxic–hyperoxic training (IHHT) may complement a multimodal training intervention (MTI) for improving cognitive function and exercise tolerance in geriatric patients. MethodsThirty-four patients (64–92 years) participated in this randomized controlled trial. Before and after the 5- to 7-week intervention period (MTI 1 IHHT vs. MTI 1 ambient air), cognitive func- tion was assessed by the Dementia-Detection Test (DemTect) and the Sunderland Clock-Drawing Test (CDT), and…

BackgroundAdditional benefits of passive exposures to intermittent hypoxia and hyperoxia on cognitive performance and functional exercise capacity have been demonstrated in geriatric patients who performed a multimodal training program. The main goal of the present study was to evaluate effects of adding intermittent hypoxic-hyperoxic training (IHHT) to a multimodal training intervention (MTI) on mobility and perceived health in old individuals at a Geriatric Day Hospital.…

OBJECTIVES: The main aim of this review was to evaluate the effectiveness of hypoxic training on the modulation of cardiometabolic risk factors. DESIGN: Literature review. METHODS: An electronic search encompassing five databases (PUBMED, EMBASE, MEDLINE, CINAHL, and SPORTDiscus) was conducted. A total of 2138 articles were retrieved. After excluding non-relevant articles, duplications and outcomes not related to cardiometabolic risk factors, 25 articles were chosen for…

The purpose of this study was to investigate the influence of hypoxic physical exercise on metabolic syndrome (MS) risk markers and high-sensitivity C-reactive protein (CRP) and to compare its effects on preperitoneal fat, arterial stiffness, and several blood parameters related to MS to those of a control group who trained under normoxic conditions. Fourteen healthy men were examined. Participants performed treadmill exercise 3 days per…

Environmental factors during fetal life program the health outcomes regarding many diseases in future life. This idea has been supported by worldwide epidemiological studies, but the underlying mechanisms are still poorly understood. Three questions should be answered. (i) Does a common underlying cause of ordinary pathological fetal development exist? (ii) If such a cause exists, which mechanism might develop disease in later life? (iii) Is…